Vol 6, No 4 (2009)

Articles
Metabolicheskiy sindrom kak protrombogennoei provospalitel'noe sostoyanie: vliyanieterapevticheskikh meropriyatiy
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Abstract
The review article highlights the main effects of therapeutic strategies on proinflammatory and procoagulant abnormalities which accompany metabolic syndrome. The main role in correction of these abnormalities belongs to dietotherapy and physical exercises. Besides, sometimes it is appropriate to use drugs which improve insulin resistance - metformin and thiazolidinediones - as they display many other positive effects, such as anti-inflammatory and anticoagulant actions.
Obesity and metabolism. 2009;6(4):3-8
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Beremennost' i ozhirenie
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Abstract
Obesity is one of the most socially significant chronic diseases, that has taken the magnitude of the epidemic, with increasing attention to obesity in pregnant women. Despite continuous improvement of surveillance system for antenatal and obstetric care, the number of pregnant women with obesity is increasing, in this connection, this problem is of special importance. The present review covers the basic mechanisms involved in development of obesity and hormonal disor-ders in pregnancy, the risks and complications associated with obesity in pregnancy. As well as measures for the prevention of excess weight before and during pregnancy.
Obesity and metabolism. 2009;6(4):9-13
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Ozhirenie v detskom vozraste:vozmozhnosti primeneniya amerikanskogokonsensusa v rossiyskoy praktike
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Abstract
We have analyzed the opportunity to use in Russian practice An Endocrine Society Clinical Practice Guideline: Prevention and Treatment of Pediatric Obesity. The document contains exact statements on diagnostic criteria of obesity and overweight, clarification of basic principles of investigation, detailed therapeutic recommendations, considerations on obesity prophylaxis problem. All recommendations are given according to the evidence database existing to the moment of guideline development. The guidelines are found to be comfortable to use by clinicians taking in consideration a few limitations. Clarifications in international pediatric percentile body mass index charts usage, nomenclature specifications, and pharmacotherapy with drugs non-approved for children are necessary.
Obesity and metabolism. 2009;6(4):14-22
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Mekhanizmy narusheniya obmena glyukozy u litss «prediabetom»
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Abstract
We have performed an estimation of metabolic disorders in 70 persons with various early glucose metabolism abnormalities (IFG and IGT). Oral glucose tolerance test (ОGTT) and intravenous glucose tolerance test (IVGTT) were done in all subjects. HbA1с, insulin and C-peptide levels were also determined. Further НОМА-R, QUICKI, MATSUDA indexes, speed of glucose elimination from the blood (k), production of glucose (H) and a degree of glucose metabolism disorders (pN) were estimated. Glucose hyperproduction and liver insulin resistance is more typical for IFG, than for isolated IGT. It was confirmed by higher parameter of liver glucose production (H) and HOMA-R index in patients with IFG. On the contrary peripheral insulin resistance is more typical for isolated IGT. Index of insulin sensitivity MATSUDA and speed of glucose elimination from the blood (k) were lower in IGT than in IFG patients. First phase of insulin secretion was broken in patients with combination IGT and IFG, which can explain the high incidence of transformation in 2 type diabetes mellitus in patients with combination IGT and IFG. The lowest HbA1c levels was found among persons with IGT. It is likely that ordinary life food intake (not glucose loading) in this group of patients does not result in chronic hyperglycemia and excessive hemoglobin glycation.
Obesity and metabolism. 2009;6(4):23-27
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Rasprostranennost' ozhireniya,kardiometabolicheskikh faktorov riska,metabolicheskogo sindroma i sakharnogo diabetasredi zhenshchin razlichnykh vozrastnykh gruppMoskovskogo regiona
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Abstract
The object of the study was to assess the frequency of visceral obesity, cardiometabolic risk factors, metabolic syndrome and diabetes mellitus in women of different ages. Materials and methods: 562 women from 20 to 65 years old were included and divided into 3 groups: 273 women < 45 years old (group A), 160 women of 45 - 55 years old (group B) and 129 - > 55 years old (group C). The examination included antropometric parameters, measurement of blood pressure, blood samples collection in order to investigate concentrations of glucose and lipids. Results: the frequency of visceral obesity was 52,0%, and metabolic syndrome - 18,1%. These frequencies increased in parallel with age. Higher insidence of arterial hypertension, hypercholesterolemia, hypertrigliceridemia and impaired fasting plasma gucose level were also observed with age. Diabetes mellitus was revealed in 1,2% of women. It`s frequency was 0,6% in group B and 4,7% in group C; in women younger than 45 years old no cases of diabetes mellitus were observed. Conclusion: significant increase of frequencies of visceral obesity, cardiometabolic risk factors, metabolic syndrome and diabetes mellitus in women older than 45, and especially - older than 55 years old stresses the necessity of an intense medical care for women of these age groups, and implementation of measures for prevention of cardiovascular diseases and diabetes mellitus.
Obesity and metabolism. 2009;6(4):28-33
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Soderzhanie leptina i pokazateli uglevodnogoobmena u bol'nykh ozhireniem posledieto-refleksoterapii
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Abstract
The article describes the results of a combined treatment by means of diet and reflexotherapy in primary obesity. After the described treatment programme the change in following parameters was observed: decrease of glucose levels, immuno-reactive insulin indices (on an empty stomach and 2 hours after taking 75g of glucose), leptin (after the course of treatment and a year later) with the association in decrease in body weight. The application of diet-reflexotherapy contributes to the decrease of appetite which results in the reduction of the amount of taken food due to rapid satiety during the meal, and allows alleviating of insulin resistance.
Obesity and metabolism. 2009;6(4):34-37
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Kompleksnyy podkhod k lecheniyu ozhireniyai metabolicheskogo sindroma u muzhchin
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Abstract
There is abdominal obesity in men that is accompanied with high risk of concomitant disease. The different authors data about close relation between obesity and metabolic syndrome with hypogonadism in men are performed in this article. Reduction of body weight due to the treatment with Xenical is accompanied by improvement of metabolic syndrome symptoms.
Obesity and metabolism. 2009;6(4):38-41
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Osobennosti metabolizma kostnoy tkanipri sindrome mnozhestvennykh endokrinnykhneoplaziy 1 tipa
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Abstract
Bone metabolism and changes in bone mineral density (BMD) are very important in patients with multiple endocrine neoplasia (MEN) type 1 syndrome. Case report: we present a clinical case of primary hyperparathyroidism (PHPT) in a patient with a familal MEN 1 syndrome and severe PHPT debuted at a young age w. Pituitary Cushing syndrome was diagnosed in 16 years old patient. He had marked osteoporosis due to hypercorticism and deficiency of sex hormones (-12% from the age norm). There was significant positive dynamics in BMD (+7% by Z-score) after remission of hypercorticism by two courses of radiation treatment and effective hormone replacement therapy of hypogonadism. PHPT with marked decrease in BMD at three sites was revealed at age of 19 years. Obvious increase in BMD was observed during a year after effective surgical treatment and antiosteoporotic therapy. In conclusion, this clinical case demonstrates the combined influence of various factors on bone metabolism in patients with MEN type 1 syndrome, which requires integrated approach to successful therapy.
Obesity and metabolism. 2009;6(4):42-46
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Have we entered the brown adipose tissue renaissance?
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Abstract
Obes Rev. 2009 May; 10(3): 265-8
Obesity and metabolism. 2009;6(4):47
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Does oestrogen allow women to store fat more efficiently? A biological advantage for fertility and gestation
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Abstract
Obes. Rev. 2009 Mar; 10(2): 168-77
Obesity and metabolism. 2009;6(4):47-48
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Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis
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Abstract
Obes. Rev. 2009 Mar; 10(2): 194-203
Obesity and metabolism. 2009;6(4):48-49
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Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women
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Abstract
Obesity (Silver Spring). 2008 Oct.; 16(10): 2281-8
Obesity and metabolism. 2009;6(4):49-50
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Intravascular kinetics of C-reactive protein and their relationships with features of the metabolic syndrome
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Abstract
J. Clin. Endocrinol. Metab. 2008 Aug; 93(8): 3158-64
Obesity and metabolism. 2009;6(4):50
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Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway
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Abstract
Diabetes. 2009 Jan.; 58(1): 87-94
Obesity and metabolism. 2009;6(4):50-51
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The interface between obesity and periodontitis with emphasis on oxidative stress and inflammatory response
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Abstract
Obes. Rev. 2009 May; 10(3): 290-7
Obesity and metabolism. 2009;6(4):51
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The dependency of vitamin D status on body mass index, gender, age and season
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Abstract
Anticancer. Res. 2009, 29(9): 3713-20
Obesity and metabolism. 2009;6(4):52
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Relationships of low serum vitamin D3 with anthropometry and markers of metabolic syndrome and diabetes in overweightand obesity
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Abstract
Nutrition Journal 2008, 7:4
Obesity and metabolism. 2009;6(4):52-53
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Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese womenand men - a cross-sectional study
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Abstract
Cardiovascular Diabetology 2009, 8:7
Obesity and metabolism. 2009;6(4):53
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Differential changes in serum uric acid concentrations in sibutramine promoted weight loss in diabetes: results from fourweeks of the lead-in period of the SCOUT trial
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Abstract
Nutr. Metab. (Lond.). 2009; 6: 42.
Obesity and metabolism. 2009;6(4):54
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Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome:a randomized, placebo-controlled, crossover trial
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Abstract
J. Clin. Endocrin. Metab., February 2010, 95(2): 1-9
Obesity and metabolism. 2009;6(4):55-56
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Spetsializirovannoe meditsinskoe pitanieGlyutserna SR v kompleksnoy terapii patsientovs sakharnym diabetom
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Abstract
Obesity and metabolism. 2009;6(4):57-62
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17-yy Evropeyskiy kongress po ozhireniyu
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Abstract
Obesity and metabolism. 2009;6(4):64-67
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