Rasprostranennost' narusheniy svertyvayushchey i protivosvertyvayushchey sistem krovi u zhenshchin s metabolicheskim sindromom v postmenopauze

Cover Page


The object of the study was to assess the prevalence of prothrombotic alterations in coagulant and anticoagulant systems among
postmenopausal women with metabolic syndrome and to determine the associations between these abnormalities and main anthropometric
measures and parameters of glucose and lipid metabolism. Cross-sectional observational study included 55 postmenopausal women
(age 45-65) with metabolic syndrome. Coagulant system was assessed by measurement of parameters of plasma haemostasis (prothrombin
index, Activated Partial Thromboplastin Time (APTT), thrombin time, fibrinogen concentration), and the activities of coagulant factors
VII (FVII) and VIII (FVIII) in plasma. In order to investigate the functioning of anticoagulant system the activities of antithrombin III
and anticoagulant system of protein C were measured. Prothrombotic alterations were observed in 81,5% women. The APTT was decreased
in 14,5%, hyperfibrinogenemia was revealed in 42,6%, the increased activity of FVII - in 50,9%, and the decreased activity
of protein C system - in 23,9%. There were a significant positive associations between some of revealed prothrombotic alterations and
anthropometric and biochemical markers of visceral obesity and metabolic syndrome (parameters of glucose and lipid metabolism).
There were no any associations between haemostatic indices and age. In conclusion, there is an evidence of high prevalence of different
prothrombotic alterations in coagulant and anticoagulant systems among postmenopausal women with metabolic syndrome. Metabolic
syndrome in postmenopause is associated with the development of prothrombotic state independently of age.

About the authors

Email: abaita@rambler.ru


  1. Бутрова С.А., Берковская М.А., Дзгоева Ф.Х., Комшилова К.А. Распространенность ожирения, кардиометаболических факторов риска, метаболического синдрома и сахарного диабета среди женщин различных возрастных групп Московского региона // Ожирение и метаболизм 2009; 4(21): С. 28-33.
  2. Долгов В.В., Свирин П.В. Лабораторная диагностика нарушений гемостаза // М. Тверь: ООО «Издательство «Триада» 2005: С. 107-11.
  3. Agewall S., Bokemark L., Wikstrand J., Lindahl A., Fagerberg B. Insulin sensitivity and hemostatic factors in clinically healthy 58-year-old men // Thromb. Haemost. 2000; 84(4): Р. 571-575.
  4. Agewall S., Bokemark L., Wikstrand J., Lindahl A., Fagerberg B. Insulin sensitivity and hemostatic factors in clinically healthy 58-year-old men // Thromb. Haemost. 2000; 84: Р. 571-155.
  5. Ainy E., Mirmiran P., Zahedi Asl. S., Azizi F. Prevalence of metabolic syndrome during menopausal transition Tehranian women: Tehran Lipid and Glucose Study (TLGS) // Maturitas 2007; 58(2): Р. 150-155.
  6. Avellone G., Di Garbo V., Cordova R., Raneli G., De Simone R., Bompiani G. Coagulation, fibrinolysis and haemorheology in premenopausal obese women with different body fat distribution // Thromb. Res. 1994; 75(3): Р. 223-231.
  7. Ay C., Tengler T., Vormittag R., Simanek R., Dorda W., Vukovich T., Pabinger I. Venous thromboembolism - a manifestation of the metabolic syndrome // Haematologica 2007; 92(3): Р. 374-380.
  8. Bahia L., Aguiar L.G., Villela N., Bottino D., Godoy-Matos A.F., Geloneze B., Tambascia M., Bouskela E. Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome // Clinics 2006; 61(5): Р. 433-440.
  9. Bjцrkelund C., Lissner L., Andersson S., Lapidus L., Bengtsson C. Reproductive history in relation to relative weight and fat distribution // Int. J. Obes. Relat. Metab. Disord. 1996; 20(3): Р. 213-219.
  10. Bos M.B., de Vries J.H., Wolffenbuttel B.H., Verhagen H., Hillege J.L., Feskens E.J. [The prevalence of the metabolic syndrome in the Netherlands: increased risk of cardiovascular diseases and diabetes mellitus type 2 in one quarter of persons under 60] // Ned Tijdschr Geneeskd 2007; 151(43): Р. 2382-2388.
  11. Bucciarelli P., Mannucci P.M. The hemostatic system through aging and menopause // Climacteric 2009; 12 Suppl 1: Р. 47-51.
  12. Carr M.C., Brunzell J.D. Increased hepatic lipase activity and intraabdominal fat across the transition from pre- to postmenopause // Program of the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA 2003; Abstract: Р. 2-280.
  13. Chu M.C., Cushman M., Solomon R., Lobo R.A. Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers // Am. J. Obstet. Gynecol. 2008; 199(5): Р. 526-527.
  14. Collins P. HDL-C in post-menopausal women: An important therapeutic target // Int. J. Cardiol. 2008; 124(3): Р. 275-282.
  15. De Pergola G., De Mitrio V., Giorgino F., Sciaraffia M., Minenna A., Di Bari L., Pannacciulli N., Giorgino R. Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution // Int. J. Obes. Relat. Metab. Disord. 1997; 21(7): Р. 527-535.
  16. Devaraj S., Rosenson R.S., Jialal I. Metabolic syndrome: an appraisal of the proinflammatory and procoagulant status // Endocrinol. Metab. Clin. North. Am. 2004; 33(2): Р. 431-453.
  17. Hidalgo L.A., Chedraui P.A., Morocho N., Alvarado M., Chavez D., Huc A. The metabolic syndrome among postmenopausal women in Ecuador // Gynecol. Endocrinol. 2006; 22(8): Р. 447-454.
  18. Janssen I., Powell L.H., Crawford S., Lasley B., Sutton-Tyrrell K. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation // Arch. Intern. Med. 2008; 168(14): Р. 1568-1575.
  19. Jensen J., Nilas L., Christiansen C. Influence of menopause on serum lipids and lipoproteins // Maturitas 1990; 12: Р. 321-331.
  20. Jou H.J., Huang H.T. Metabolic syndrome: menopausal women and the health care challenge // Taiwan. J. Obstet. Gynecol. 2009; 48(3): Р. 205-209.
  21. Kahn S.E., Zinman B., Haffner S.M., O'Neill M.C., Kravitz B.G., Yu D., Freed M.I., Herman W.H., Holman R.R., Jones N.P., Lachin J.M., Viberti G.C. ADOPT Study Group. Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes // Diabetes 2006; 55(8): Р. 2357-2364.
  22. Kim H.M., Park J., Ryu S.Y., Kim J. The effect of menopause on the metabolic syndrome among Korean women: the Korean National Health and Nutrition Examination Survey, 2001 // Diabetes Care 2007; 30(3): Р. 701-706.
  23. Li Z., McNamara J.R., Fruchart J.C., Luc G., Bard J.M., Ordovas J.M., Wilson P.W., Schaefer E.J. Effects of gender and menopausal status on plasma lipoprotein subspecies and particle sizes // J. Lipid. Res. 1996; 37: Р. 1886-1896.
  24. Lobo R.A. Metabolic syndrome after menopause and the role of hormones // Maturitas 2008; 60(1): Р. 10-18.
  25. Lуpez Suбrez A., Elvira Gonzбlez J., Beltrбn Robles M., Alwakil M., Saucedo J.M., Bascuсana Quirell A., Barуn Ramos M.A., Fernбndez Palacнn F. [Prevalence of obesity, diabetes, hypertension, hypercholesterolemia and metabolic syndrome in over 50-yearolds in Sanlъcar de Barrameda, Spain] // Rev. Esp. Cardiol.; 61(11): Р. 1150-1158.
  26. Marcucci R., Abbate R., Fedi S., Gori A.M., Brunelli T., Bruni V., Bucciantini S., Micheli S., Pepe G., Prisco D., Gensini G.F. Acquired activated protein C resistance in postmenopausal women is dependent on factor VIII:c levels // Am. J. Clin. Pathol. 1999; 111(6): Р. 769-772.
  27. Nieuwdorp M., Stroes E.S., Meijers J.C., Buller H. Hypercoagulability in the metabolic syndrome // Curr. Opin. Pharmacol. 2005; 5(2): Р. 155-159.
  28. Peverill R.E., Teede H.J., Malan E., Kotsopoulos D., Smolich J.J., McGrath B.P. Relationship of waist and hip circumference with coagulation and fibrinolysis in postmenopausal women // Clin. Sci. (Lond) 2007; 113(9): Р. 383-391.
  29. Poehlman E.T., Toth M.J., Ades P.A., Rosen C.J. Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study // Eur. J. Clin. Invest. 1997; 27(4): Р. 322-326.
  30. Poehlman E.T., Toth M.J., Gardner A.W. Changes in energy balance and body composition at menopause: a controlled longitudinal study // Ann. Intern. Med. 1995; 123(9): Р. 673-675.
  31. Połać I., Stachowiak G., Jedrzejczyk S., Pertyński T., Sobczuk A., Pakalski A., Stetkiewicz T., Owczarek D. [Assessment of fat tissue distribution impact on selected prothrombin and fibrinolytic factors in pre- and postmenopausal women] // Ginekol. Pol. 2000; 71(9): Р. 1083-1088.
  32. Połać I., Stetkiewicz T., Stachowiak G., Jedrzejczyk S., Pertyński T., Pakalski A., Kowalska E. [Evaluation of the effect of obesity on selected haemostatic and fibrinolytic parameters in peri- and postmenopausal women] // Pol. Merkur. Lekarski 2002; 13(75): Р. 182-184.
  33. Ragab A., Abousamra N.K., Higazy A., Saleh O. Relationship between insulin resistance and some coagulation and fibrinolytic parameters in patients with metabolic syndrome // Lab. Hematol. 2008; 14(1): Р. 1-6.
  34. Royer M., Castelo-Branco C., Blьmel J.E., Chedraui P.A., Danckers L., Bencosme A., Navarro D., Vallejo S., Espinoza M.T., Gуmez G., Izaguirre H., Ayala F., Martino M., Ojeda E., Onatra W., Saavedra J., Tserotas K., Pozzo E., Manriquez V., Prada M., Grandia E., Zuniga C., Lange D., Sayegh F. Collaborative Group for Research of the Climacteric in Latin America. The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III): prevalence of the metabolic syndrome in postmenopausal Latin American women // Climacteric 2007; 10(2): Р. 164-170.
  35. Sakkinen P.A., Wahl P., Cushmann M., Lewis M.R., Tracy R.P. Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome // Am. J. Epidemiol. 2000; 152: Р. 897-907.
  36. Scarabin P.Y., Vissac A.M., Kirzin J.M., Bourgeat P., Amiral J., Agher R., Guize L. Population correlates of coagulation factor VII. Importance of age, sex, and menopausal status as determinants of activated factor VII // Arterioscler. Thromb. Vasc. Biol. 1996; 16(9): Р. 1170-1176.
  37. Solб E., Vayб A., Villa P., Espaсa F., Estellйs A., Garcнa K., Hernбndez-Mijares A. Obesity and activated protein C resistance // Pathophysiol. Haemost. Thromb. 2008; 36(2): Р. 64-68.
  38. Stachowiak G., Połać I., Woźniak P., Pertyński T., Pawłowicz P., Jedrzejczyk S., Makuła A. [Evaluation of coagulation and fibrinolysis systems in women at peri- and postmenopausal age qualified for hormone replacement therapy] // Ginekol. Pol. 2000; 71(9): Р. 1110-1114.
  39. Swiatkowska-Stodulska R., Skibowska-Bielińska A., Bakowska A., Wiśniewski P., Sworczak K. [Assessment of selected haemostatic parameters in obese patients] // Endokrynol. Pol. 2007; 58(6): Р. 505-509.
  40. Toth M.J., Tchernof A., Sites C.K., Poehlman E.T. Effect of menopausal status on body composition and abdominal fat distribution // Int. J. Obes. Relat. Metab. Disord. 2000; 24(2): Р. 226-231.
  41. Wannamethee S.G., Lowe G.D., Shaper A.G., Rumley A., Lennon L., Whincup P.H. The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men // Atherosclerosis 2005; 181(1): Р. 101-108.
  42. Zamboni M., Armellini F., Milani M.P., De Marchi M., Todesco T., Robbi R., Bergamo-Andreis I.A., Bosello O. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships // Int. J. Obes. Relat. Metab. Disord. 1992; 16(7): Р. 495-504.



Abstract - 1096

PDF (Russian) - 458



Copyright (c) 2010 Berkovskaya M.A., Butrova S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies