The «cut-off point» of vitamin D: a method of suppressing excessive secretion of PTH
https://doi.org/10.14341/omet10196
Abstract
BACKGROUND: The subject of discussion is the issue of the separation point, which determines sufficient levels of vitamin D for bone health. When determining the adequate reference range of vitamin D, researchers are mainly guided by the results of research, where the level of 25(OH)D is determined, at which the PTH level decreases and reaches a plateau.
AIM: To establish the «cut-off point» of vitamin D by suppressing excessive secretion of PTH.
MATERIALS AND METHODS: Observational, single-site, single-stage, selective, uncontrolled study of the search for vitamin D levels by the effect on PTH secretion in residents of Tyumen region was conducted (n = 176). All selected study participants determined the level of 25(OH)D and PTH in serum. The calculation of the «cut-off point» was carried out using the method of searching for changes in the correlation dependence of PTH on the level of vitamin D, followed by verification of the data obtained using ROC analysis.
RESULTS: A mathematical analysis of the dependence of 25(OH)D and PTH showed the “cut-off point” of vitamin D, equal to – 23.6 ng/ml.
CONCLUSION: The “cut-off point” of 23.6 ng/ml is optimal for suppressing excessive PTH secretion. The data obtained may be an incentive for further working out the “cut-off point” of vitamin D for the Russian population and can be used to clarify the classification of deficiency, insufficiency and optimal levels of vitamin D for the population of the Russian Federation.
About the Authors
Liudmila A. Suplotova
Tyumen State Medical University
Russian Federation
MD, PhD, Professor
Russian Federation
MD, PhD, Professor
Valeria A. Avdeeva
Tyumen State Medical University
Russian Federation
Russian Federation
MD, postgraduate
Ekaterina A. Pigarova
Endocrinology Research Centre
Russian Federation
Russian Federation
MD, PhD
Liudmila Ya. Rozhinskaya
Endocrinology Research Centre
Russian Federation
Russian Federation
MD, PhD, Professor
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Supplementary files
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1. Figure 1. Dependence of ln (PTH) on 25 (OH) D. The black line shows the optimal regression dependence to the right and left of the value of 23.6. | |
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2. Figure 2. ROC-curve for calculating the separation point from the received data | |
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Review
For citations:
Suplotova L.A., Avdeeva V.A., Pigarova E.A., Rozhinskaya L.Ya. The «cut-off point» of vitamin D: a method of suppressing excessive secretion of PTH. Obesity and metabolism. 2019;16(3):88-93. (In Russ.) https://doi.org/10.14341/omet10196
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