Vol 5, No 2 (2008)

Articles
Effect of thiazolidinediones on insulin resistance and cardiovascular risk factors
Demidova T.Y., Erokhina E.N.
Abstract
The development of new, more effective ways of multivariate control of type 2 diabetes is currently the most important problem of endocrinology. This is caused by a high prevalence of this disease in the population, as well as a significant risk of complications leading to early morbidity and mortality of patients. Clinical management of patients with type 2 diabetes should be based on a thorough study of the mechanisms of this disease in order to correct the basic pathogenetic defects.
Obesity and metabolism. 2008;5(2):2-5
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Psychological aspects of diet therapy in type 2 diabetes mellitus
Starostina E.G.
Abstract
The importance of studying the psychological aspects of nutrition diet is, perhaps, the most commonly used words in the lexicon of Endocrinology and Diabetology and most unpleasant - for patients with diabetes mellitus (DM). Any restrictions on certain aspects of nutrition in patients with diabetes create a negative attitude to the disease, since they require non-established habits and tastes, a significant change in lifestyle, often - constant "struggle" with gusto. And if type 1 diabetes decrease dietary restrictions for patient education - the so-called liberalized diet - allows much to make life easier to patient without compromising compensation diabetes [3, 11], the rules for type 2 diabetes, especially in combination with obesity, are fundamentally based on constraints.
Obesity and metabolism. 2008;5(2):7-10
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The prevalence of type 2 diabetes and glucose intolerance in the adult population of the Moscow region
Dreval' A.V., Misnikova I.V., Barsukov I.A., Ponchakova G.V., Kuznetsov A.V.
Abstract
Currently in Russia, as well as throughout the world, has been steadily increasing prevalence of type 2 diabetes and early disorders of carbohydrate metabolism - impaired glucose tolerance and impaired fasting glucose. It is shown that in the first year after diagnosis "prediabetes" in 5-10% of patients becomes type 2 diabetes, in five years - at 20-35%. If impaired glucose tolerance combined with impaired fasting glucose, the type 2 diabetes within 5 years develops in 38-65%. The true prevalence of overt type 2 diabetes several times higher than registered, from time to onset of the disease before its detection can reach 7-12 years. Up to 50% of patients with type 2 diabetes at diagnosis already have those or other complications. In this case, early detection of type 2 diabetes and early disorders of carbohydrate metabolism contributes to the timely initiation of treatment and prevention of complications of diabetes, can lead to disability of the patient. The aim of this study was to determine the results of oral glucose tolerance test the prevalence of type 2 diabetes and early disorders of carbohydrate metabolism among a select group of the adult population of the Moscow region.
Obesity and metabolism. 2008;5(2):11-16
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The effectiveness of metformin in patients with metabolic syndrome and nonalcoholic fatty liver disease
Butrova S.A., Eliseeva A.Y., Il'in A.V.
Abstract
The mechanism of action of metformin is realized through activation of cAMP-dependent protein kinase, leading to a decrease hepatic glucose production as well as to decrease the synthesis of triglycerides and an increase in fat oxidation. Several studies have demonstrated the positive effect of the drug in non-alcoholic fatty liver disease, manifested in reducing the activity of enzymes, reducing the size of the liver and insulin resistance. The aim of our study was to evaluate the effectiveness of metformin in patients with metabolic syndrome and nonalcoholic fatty liver disease. The study found that the use Siofor 850 mg 2 times a day in conjunction with a reduced-calorie nutrition in patients with metabolic syndrome and nonalcoholic fatty liver disease leads to a significant reduction in insulin resistance associated with decreased activity of transaminases, improvement of metabolic parameters. The therapy Siofor majority of patients (60%) with metabolic syndrome and nonalcoholic fatty liver disease achieved a clinically significant weight loss and improved body composition. Application Siofor improves lifestyle changes in obese patients with non-alcoholic liver disease dirovoy and metabolic disorders.
Obesity and metabolism. 2008;5(2):17-21
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Osobennosti adaptatsii novorozhdennykh u materey s ozhireniem
Zernova L.Y., Kovalenko T.V., Popova N.N., Strelkov N.S.
Abstract
According to various authors, obesity among pregnant recorded at a frequency of 15.5 to 26.9%. There is strong evidence that obesity contributes to complications of pregnancy, childbirth and the postpartum period, provoking the development of gestosis, placental insufficiency, abnormalities of labor, bleeding, et al., Which suggests the possibility of adjustment disorder in the neonatal period in infants of obese mothers. It should be recognized, however, that the available information on the subject are scarce and fragmentary. The purpose of this study was to investigate the features of postnatal adaptation of newborns of mothers with obesity. According to the study found that obesity in women is associated with a high incidence of reproductive disorders, gestational complications and pathological course of labor, resulting in abnormalities in the neonatal adaptation in the postnatal period. Disadaptation syndrome is manifested by the development of jaundice sustained over, edema, transient changes of the cardiovascular system, hypoglycemia. Violations in health are detected in the majority of infants (83.3%) born to mothers with obesity. The most significant pathologies are infections specific to the perinatal period (40.5%), respiratory distress syndrome (3.6%), diabetic fetopathy (4.8%), congenital malformations (2.4%).
Obesity and metabolism. 2008;5(2):23-26
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Efficiency Biliopancreatic bypass surgery in bulimia nervosa
Yashkov Y.I., Bekuzarov D.K., Nikol'skiy A.V.
Abstract
A clinical significance in the treatment of bulimia nervosa patients with morbid obesity had already been raised [10, 13], but we did not find publications on the effectiveness of bariatric surgery in these cases. There is also information about the possibility of applying the operation bilio-pancreatic bypass, effective in patients with morbid obesity with uncontrolled eating behavior for the treatment of patients with anorexia BILIM not suffering from morbid obesity. In this article the data of clinical observation of a small sample of patients. As a result, the treatment of these patients found that severe nervous BILIM can be seen as a latent form of morbid obesity. The choice of treatment should depend not only on the initial body weight of the patient, but also on the severity of the nervous BILIM. Unsuccessful attempts at organized-balanced, conservative treatment of patients with severe bulimia nervosa may be considered a variant of surgical treatment, while bilio-pancreatic bypass surgery is considered as the most preferred operation, compared with the installation of the gastric balloon and others. All candidates for surgical treatment of obesity must identify clinical signs of bulimia nervosa, as this may influence the choice of method of operation. Further study of the role of hyperinsulinemia, secretion of ghrelin, leptin, intestinal peptide may contribute to the elucidation of the true causes of bulimia nervosa, probably has a similar origin with morbid obesity.
Obesity and metabolism. 2008;5(2):27-31
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Experience of using Xenical for pilots
Ametov A.S., Belykh A.A.
Abstract
Lack of exercise, hypoxia, stress, constant psychological stress, longer shifts, a violation of the feeding process contribute to the development of metabolic disorders. Thus, persons Summer Special can be seen as a model for the study of risk factors for type 2 diabetes and the development of optimal preventive measures that determined the relevance and purpose of the study. The purpose of research - to evaluate the effectiveness of the correction of overweight and disorders of carbohydrate and lipid metabolism in patients with risk factors for type 2 diabetes. For the correction of body weight was used Orlistat (Xenical) - specific inhibitor of gastrointestinal lipases, acting locally in the lumen of the gastrointestinal trakta.Materialy and methods The study was performed at the Central Clinical Hospital of Civil Aviation. The study found that those aircrew who are overweight are at high risk of developing type 2 diabetes, which is due on the one hand, metabolic disorders due to abdominal obesity, and on the other - especially the professional activity (physical inactivity, a violation of the process food, emotional stress). As an effective therapy to persons aircrew appropriate to recommend treatment with Xenical against the background of a moderately hypocaloric diet combined with the expansion of physical activity.
Obesity and metabolism. 2008;5(2):33-37
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Menstrual and reproductive function repair in patients with polycystic ovary syndrome and obesity by correcting of glucose intolerance
Lineva O.I., Glukhova M.V.
Abstract
The aim of the study was to investigate the effect of sibutramine on metabolic and hormonal parameters in women with PCOS and obesity. Materials and methods. The study included 53 women aged 18 to 35 years (mean age 31,3 ± 1,1 years) with PCOS and obesity. All patients received therapy with sibutramine. The total treatment duration was 6 months. The treatment was evaluated monthly nature of the menstrual cycle, anthropometric parameters (body weight, BMI, ON, ON, ON / OF). The Results. The studies found that after 3 months of treatment with weight loss was 8,1 ± 0,31 kg, after 6 months - 13,1 ± 0,78 kg (p <0,05). Results of the survey of women included in this study strongly support the negative impact of obesity on the functional state of the reproductive system, evidenced by the high incidence of anovulation, rhythm disturbances of menstruation (amenorrhea up to), infertility. Conclusions. The obtained results once again confirm the high efficacy and safety of sibutramine to reduce body mass, suggest correction of metabolic, hormonal disorders and positive impact on women's reproductive health. This allows us to consider the use of sibutramine in women with PCOS and obesity as a way to restore the endocrine function of the reproductive system.
Obesity and metabolism. 2008;5(2):38-41
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Masks of Schwartz-Bartter Syndrome clinical pictures: a case report
Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Y.
Abstract
Schwartz-Bartter Syndrome (synonyms: syndrome of inappropriate secretion of antidiuretic hormone syndrome of inappropriate secretion of vasopressin, anti-diabetes insipidus) - this is a rare disease characterized by excessive secretion of antidiuretic hormone (ADH) from the posterior pituitary, or other source, resulting in developing hyponatremia and water intoxication. Hyponatremia dilutions at Schwartz-Bartter Syndrome is usually non-specific symptoms, such as headache, nausea, vomiting and confusion. Marked reduction in blood sodium levels may lead to seizures or even coma.
Obesity and metabolism. 2008;5(2):42-44
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World endocrinology news
Berkovskaya M.A.
Abstract
The role of interleukin-6 in insulin resistance, body fat distribution and energy balance Disorders of glucose metabolism and risk of oral cancer. Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife--SWAN, the study of women's health across the nation. Vitamin D deficiency and risk of cardiovascular disease. Adypocyte prolactin: regulation of release and putative functions.
Obesity and metabolism. 2008;5(2):45-54
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