Vol 7, No 1 (2010)

Articles
Cindrom obstruktivnogo apnoe sna v praktikevracha-endokrinologa
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Abstract
It is known, that sleep-disordered breathing can affect patients with various endocrine diseases. Obstructive, central and mixed types of sleep apnea syndrome are known to occur in obesity, hypothyroidism, acromegaly, diabetes mellitus, especially with diabetic neuropathy, Cushing syndrome and polycystic ovary syndrome. The pathogenic mechanisms and pathophysiology of оbstructive sleep apnea in patients with different endocrine diseases, clinical manifestations and treatment of sleep apnea are reviewed in this article.
Obesity and metabolism. 2010;7(1):3-10
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Vliyanie perinatal'nykh faktorov na razvitieozhireniya vo vzroslom vozraste
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Abstract
The studies of perinatal factors long-term effects on obesity development are summarized in this article. Maternal body mass and nutrition role during pregnancy was demonstrated in Dutch hunger studies and several works in vivo. The association between birth weight, obesity, and abdominal fat distribution in future life were demonstrated several times. Breast feeding duration and risk of obesity have inverse association, but excessive breast feeding also can increase obesity risk. Early accelerated weight gain and further risk of obesity are also associated. Based on the effect of nitrition in preterm newborns study and several works in vivo it is hypothesized that increased food consumption during infancy can program elevated leptin concentrations for fat mass ratio durng future life. Further investigations in this area can lead to breakthrough in solving the problem of obesity and overweight prophylaxis.
Obesity and metabolism. 2010;7(1):11-14
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Vliyanie tabakokureniya na zdorov'e i massu telacheloveka
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Abstract
Tobacco smoking causes a lot of human deseases and is one of the main reasons of premature death. Smoking cessation is very important for the patient's health but difficult for them due to development of nicotine dependence. Tobacco dependence is a chronic disease. Smoking Cessation Clinical Practice Guideline, published in 2008, emphasize the dire health consequences of tobacco dependence, regulate the way of treating patients who want to quit smoking, recommending the use of effective treatments, including counseling and medications. Seven first-line medications (5 nicotine and 2 non-nicotine, including Varenicline) that reliably increase long-term smoking abstinence rates are now available. Smoking cessation is accompanied by a moderate weigh gain. And its a strong motivational factor to continue smoking, espcially for women. Сounseling, healthy food and physical activity are recommended for such patients.
Obesity and metabolism. 2010;7(1):15-19
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Metabolicheskiy effekt gormona rostapri gipopituitarizme u vzroslykh
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Abstract
Review coverts the basic metabolic disorders, characteristic for adult patients with hypopituitarism which frequently cannot be solved by means of traditional replacement hormonal therapy. Positive influence of rGH therapy has proved necessity of its application for these patients. Complex replacement of all pituitary deficiencies, including GH, allows an organism to work in the conditions of the hormonal metabolism as much as possible similar to normal, completely leveling or reducing to a minimum of metabolic consequences common for adults with hypopituitarism.
Obesity and metabolism. 2010;7(1):21-27
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Dzheneriki pri lechenii ozhireniya
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Abstract
There are several pseudogenerics of Meridia® and Xenical®. Lindaxa®, registered in Russia, as a generic of Meridia®, can be at a disadvantage to a brand on cost-quality ratio.
Obesity and metabolism. 2010;7(1):28-32
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Ksenikal v kompleksnom lechenii patsientovs izbytochnoy massoy tela i ozhireniem
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Abstract
This article shows a significant efficacy and safety data of original drug Xenical in complex treatment of overweight and obesity patients. It is emphasized that this data describe properties of original Xenical, but not generics. The generic drug Orsoten has completely different physicochemical characteristics comparing to Xenical, this differences may lead to increase in allergic reactions and increase of frequency and intensity of side effects.
Obesity and metabolism. 2010;7(1):34-39
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Leptin u zhenshchin, bol'nykh sakharnym diabetom2 tipa, ne poluchayushchikh lekarstvennuyusakharosnizhayushchuyu terapiyu
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Abstract
The aim of this study was to investigate the effect of acute hyperinsulinemia to fasting leptin level (fL) secretion and leptin secretion during intravenouse glucose tolerance test (IVGTT). Methods. 32 T2DM women without antidiabetic drugs were studied. Median age of participants was 57,5[50,0;62,5] years, median body mass index (BMI) was 32,7[29,1;37,1]. Glucose intravenouse bolus solution (40%) was dosing (0,75 g/kg BM). Insulin level was investigated in fasting state (FI), 2 min, 70 min and 120 min after glucose loading. Leptin was investigated in fasting (FL) and 120 min after glucose loading. Results. FL level was 21,1[13,6;39,0] ng/ml. Relationships between FL and HOMA-R, аnd between FL and FI were enough strong (r=0,5, р<0,05). FL in the patient with moderate diabetes control was twice as much compared to FL in patients with poor diabetes control: (28,0[16,8;47,5] v.s. 12,6[9,2;14,3] ng/ml, (р<0,05)). We found a significant decrease in leptin level at 120 min IVGTT (11% from FL, (р<0,05)). The most reduction of leptin level was in moderate diabetes control group, which had the overall area under insulin curve. We discovered a correlation between percentage of leptin reduction and insulin increase on 70 minute of IVGTT (r=0,5, р<0,05). Inverse correlation was found between percent of leptin reduction in IVGTT and high density lipoprotein level (r=-0,4, р<0,02). Conclusion. FL in moderate diabetes control group was two times higher compared to poor diabetes control group. Leptin level after glucose loading was decreased compared with FL.
Obesity and metabolism. 2010;7(1):41-45
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Opyt primeneniya preparata Orsoten (orlistat)u bol'nykh ozhireniem
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Abstract
At present, the epidemic of overweight and obesity is one of the most pressing public health problems worldwide. Pharmacotherapy is often initiated to increase the effectiveness of obesity therapy, including orlistat, which is a long-acting inhibitor of gastric and pancreatic lipases that reduces splitting and subsequent absorption of fat food. Till the recent time the only available orlistat preparation was Xenical (F. Hoffman La Roche Ltd, Switzerland). In 2009, in Russia was registered another trade name of drug - Orsoten (KRKA, Slovenia), which is the first generic drug orlistat. The article shows the results of a study conducted to examine the clinical equivalence, efficacy and safety of the drug Orsoten compared with Xenical in obese patients.
Obesity and metabolism. 2010;7(1):46-50
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Effekty dlitel'nogo primeneniya estrogen-gestagennoy terapii u zhenshchin reproduktivnogovozrasta s izolirovannym gipogonadotropnymgipogonadizmom
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Abstract
We examined 56 normoprolactinemic women of reproductive age (18-45 y.o.) with isolated hypogonadotropic hypogonadism (group 1) initially and on treatment with 2 mg of 17beta-estradiol and 10 mg of dydrogesterone in sequenced manner (HRT), duration of HRT was from 18 to 42 (median 36) months; 45 healthy women (20-38 y.o.) were included in control group 2. Initially hypercholesterolemia was observed in 50% of cases in group 1 and 6.6% in group 2 (z=12,29, p=0,0005); nevertheless, the difference in lipid levels between groups 1 and 2 was not statistically significant: total cholesterol levels 5,2 (4,3; 6,0) mmol/l and 4,63 (4,15; 5,15) mmol/l respectively (1vs2, р=0,1); triglycerides 0,8 (0,62; 1,3) mmol/l and 0,76 (0,6; 0,85) mmol/l (1vs2, р=0,08); HDL 1,89 (1,24; 2,1) mmol/l and 1,79 (1,44; 2,8) mmol/l (1vs2, p=0,85); LDL 2,7 (2,2; 3,2) mmol/l and 2,75 (2,3; 3,3) mmol/l (1vs2, p=0,64). In group 1 decrease of total cholesterol and triglycerides concentrations was found on HRT: total cholesterol 4,8 (3,95; 5,1) mmol/l (before vs on treatment p=0,041), triglycerides 0,65 (0,6; 0,9) (before vs on treatment p=0,044) respectively, changes in HDL and LDL levels were not revealed. Initial concentrations of Ca++, P, and alkaline phosphatase (AP) were within normal range in all women. However, concentrations of Ca++ and AP were higher in group 1 compared to group 2: Ca++ 1,13 (1,08; 1,19) mmol/l and 1,05 (1,03; 1,09) mmol/l (1vs2, p=0,0016); AP 161,5 (141,8; 183) IU/l and 141,0 (119; 151) IU/l (1vs2, p=0,044). On HRT reduce in Ca++ and AP concentrations was observed: Ca++ concentrations 1,05 (1,03; 1,10) mmol/l (before vs on treatment p=0,004), AP 139 (112; 143) IU/l (before vs on treatment p=0,004). HRT was accompanied by improvement of clinical symptoms, had no influence on thyroid function, and provoked physiological rise of prolactin levels.Thus, despite lacking the expressed biochemical disorders, isolated hypogonadotropic hypogonadism in women of reproductive age have hidden negative impact on lipid and mineral metabolism. Long term HRT is safe and significantly improved parameters of lipid and mineral homeostasis in this cohort of patients.
Obesity and metabolism. 2010;7(1):52-57
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Osobennosti zhirovogo obmena pri bolezniItsenko-Kushinga
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Abstract
The reported clinical case represents an example of characteristic traits in lipid metabolism and fat tissue deposition in hypercorticosolism. Probable causes for fat mass expansion in glucocorticosteroid excess, its distinctive cushingoid distribution, role of 11β-HSD1 and glucocorticoid receptors and reversibility of specific abnormalities after correction of hypercortisolism are discussed in the context of physiological and pathological aspects of glucocorticosteroid action.
Obesity and metabolism. 2010;7(1):58-62
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Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Forceon Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World HeartFederation; International Atherosclerosis Society; and International Association for the Study of Obesity
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Abstract
Circulation, 2009, Oct. 20; 120(16): 1640-5
Obesity and metabolism. 2010;7(1):63-65
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Is it time to test metformin in breast cancer clinical trials?
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Abstract
Cancer Epidemiol Biomarkers Prev., 2009, Mar.;18(3): 701-5.
Obesity and metabolism. 2010;7(1):65-66
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Gut microbiota and its possible relationship with obesity
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Abstract
Mayo Clin Proc., 2008, Apr.; 83(4): 460-9
Obesity and metabolism. 2010;7(1):68-68
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Are metabolically normal but obese individuals at lower risk for all-cause mortality?
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Abstract
Diabetes Care, 2009, Dec.;32(12): 2297-9.
Obesity and metabolism. 2010;7(1):69-69
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The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
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Abstract
Gut., 2009, Nov.; 58(11): 1538-44. Epub, 2009, Jul. 21
Obesity and metabolism. 2010;7(1):69-70
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Breastfeeding in infancy and adult cardiovascular disease risk factors
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Abstract
Am. J. Med., 2009, Jul.; 122(7): 656-63.e1.
Obesity and metabolism. 2010;7(1):71
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Plasma alpha-melanocyte-stimulating hormone: sex differences and correlations with obesity
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Abstract
Metabolism, 2009, Jan.; 58(1): 16-21
Obesity and metabolism. 2010;7(1):71-72
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High prevalence of microalbuminuria in the overweight and obese population: data from a UK population screening programme
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Abstract
Nephron Clin Pract 2009; 112(3): 205-212
Obesity and metabolism. 2010;7(1):72
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Influence of obesity on progression of non-diabetic chronic kidney disease: a retrospective cohort study
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Abstract
Nephron Clin Pract 2009, 113 (1): p. 16-23
Obesity and metabolism. 2010;7(1):73
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Early histological changes in the kidney of people with morbid obesity
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Abstract
Neprol Dial Transplant 2009 Dec., 24(12): 3732-3738
Obesity and metabolism. 2010;7(1):74
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Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations. Climacteric. 2009 Sep 1:1-11.
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Abstract
Obesity and metabolism. 2010;7(1):74-75
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«Diagnostika i lechenie ozhireniya u vzroslykh»Proekt rekomendatsiy ekspertnogo komitetaRossiyskoy assotsiatsii endokrinologovPublikuetsya dlya shirokogo obsuzhdeniya
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Abstract
Obesity and metabolism. 2010;7(1):76-81
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Rossiyskie i mezhdunarodnyekonferentsii i s\"ezdy 2010 goda
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Abstract
Obesity and metabolism. 2010;7(1):82-82
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14-y Vsemirnyy kongress Mezhdunarodnoyfederatsii khirurgii ozhireniya i metabolicheskikhnarusheniy26-29 avgusta 2009 g., Parizh (Frantsiya)
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Abstract
Obesity and metabolism. 2010;7(1):83-85
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Spetsializirovannoe meditsinskoe pitanie«Glyutserna® SR» dlya lyudey, stradayushchikh sakharnymdiabetom
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Abstract
Obesity and metabolism. 2010;7(1):86-86
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