Vol 10, No 3 (2013)

Articles
Perspectives in the treatment of breast cancer in postmenopausal women who are overweight and obese
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Abstract
Overweight and obesity in postmenopausal women are risk factors for breast cancer. Identifying features of the pathogenesis of the disease in this group of patients has led to the emergence of new trends in treatment and prevention. The article presents data on the anti-cancer effects of metformin, nonsteroidal anti-inflammatory drugs and vitamin D
Obesity and metabolism. 2013;10(3):3-10
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Obesity and sleep
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Abstract
Over the past decade in many countries of the world are an increasingly serious problem of sleep disorders and it coincides with the growing incidence of obesity. Complexity of pathogenesis links between the abnormalities consists of factors that influence the development and progression of obesity and directly to sleep. The most common sleep disorders in obese patients – obstructive sleep apnea and insomnia syndrome. This review provides information of correlation between obesity and sleep disorders, in which a key role is a hormones secretion changing which regulate appetite and energy balance
Obesity and metabolism. 2013;10(3):11-18
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The problem of choosing between the original and of generic drugs in patients with overweight and obesity
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Abstract
This review article discusses the similarities and differences in the research, production and use in clinical practice, original and generic drugs. Reproduced drugs (generics) present on the Russian pharmaceutical market that have the bioequivalence data are not always equal in therapeutic equivalence of the original drug. The article presents evidence base of efficacy and safety of the original drug Xenical in the complex treatment of patients with overweight and obesity.
Obesity and metabolism. 2013;10(3):19-26
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Status of carbohydrate and lipid metabolism in obese patients with type 2 diabetes mellitus after biliopancreatic diversion surgery
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Abstract
We examined 70 patients with obesity and diabetes mellitus type 2 before and within 5 years after BPD: these patients showed a significant improvement in the status of carbohydrate and lipid metabolism within 3 months after surgery. This improvement has remained stable along with the reduced body weight during the whole observation period of up to 5 years.
Obesity and metabolism. 2013;10(3):28-36
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Three-year efficacy study of patients with a high cardiovascular risk in a population of organized industrial city of the Far North
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Abstract
We studied the structure and dynamics of the prevalence of modifiable risk factors in 104 patients with metabolic syndrome. It is established that the therapeutic effect is short-term training (3 months ) and a long-term care retraining only leads to a decrease in the prevalence of risk factors for chronic noncommunicable diseases. The relative likelihood of achieving the desired weight loss, according to a three-year prospective study on the background of relearning in higher 2.7 times.
Obesity and metabolism. 2013;10(3):37-43
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Hypoglycemia episodes after biliopancreatic diversion for morbid obesity: clinical case presentation
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Abstract
Modifications of glucose metabolism are observed after bariatric surgery and are attributed to the increased release of incretins – biologically active gut peptides. Hypoglycemia episodes after bypass operations are mostly of functional origin (dumping syndrome) and can be corrected by dietary recommendations. At the same time multiple cases of nesidioblastosis in patients, who underwent gastric bypass surgery are reported. This article is focused on a clinical case of postprandial hypoglycemia in patient after biliopancreatic diversion for morbid obesity
Obesity and metabolism. 2013;10(3):44-49
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The gravicentric Concept in type 2 Diabetes: practical implementation
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Abstract
The epidemic rise of patients with type 2 diabetes mellitus (T2DM) worldwide continues, despite all efforts taken by the international medical community to curb it. It seems that the advent of new drugs does not contribute to a better control of the disease, the tightening up of diagnostic criteria causes an abrupt increase in the number of patients, while a revision of the main goals of treatment (a reduction of targets for glycemic control) often becomes an argument in favor of an overly aggressive approach to drug therapy in diabetes. The main therapeutic goal of existing algorithms for the management of T2DM patients is to achieve and maintain long-term indicators of glycemic control, as close to normal values as possible. However, almost none of these algorithms address the factors associated with the pathogenesis of development and progression of the underlying disease, such as lack of exercise and excessive adiposity. For the sake of achieving glycemic target values, patients often receive treatment that is known to be conducive to weight gain, insulin resistance and increased progression of relative insulin deficiency, eventually leading to the prescription of exogenous insulin. At the same time, an active modification of the pathogenetic factors of T2DM – excess body weight and physical inactivity – may lead to restoration of glucose tolerance, reducing the need of pharmacotherapy until its complete withdrawal, as has been shown in many major studies [2]. The "gravicentric concept" of treatment of T2DM is designed to redefine the basic therapeutic targets and change the emphasis in the of patients' management scheme. Its mission is to create a clear idea for both doctors and patients about the possibility of de-intensification of pharmacotherapy under certain conditions, and to focus maximum effort to address the factors of progression of the disease with the hope of a cure or remission
Obesity and metabolism. 2013;10(3):50-54
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Endokrinnye disraptory – khimicheskie veshchestva, narushayushchie funktsii endokrinnoy sistemy: rasskaz o bisfenole A
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Abstract
Obesity and metabolism. 2013;10(3):55-57
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Prevention of deterioration of bone microarchitectonics with metformin in diabetes with insulin deficiency
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Abstract
Obesity and metabolism. 2013;10(3):58-58
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Metformin reduces the need for levothyroxine in patients with hypothyroidism and type 2 diabetes mellitus
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Abstract
Obesity and metabolism. 2013;10(3):60-61
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