Relationship of IGF-1 and cardiac remodeling in overweight patients


Objectives: To investigate the role of IGF-1 in the development of cardiac remodeling in patients with overweight and mild obesity.

Materials and Methods: The study included 75 men (mean age 55.3 ± 6.3 years), which are overweight or have mild obesity (body mass index (BMI) 28.6 ± 3.6) without diabetes. Group 1 included 46 patients with normal weight and overweight (BMI 26.5 ± 3.6). Group 2 included 27 patients with obesity (mean BMI 32.4 ± 3.5). Coronary artery disease was confirmed by treadmill test and coronarography. All participants were evaluated by impaired glucose tolerance test (IGT), cholesterol, triglycerides (TG), IGF-1 and LPHD, and LPLD levels, geometry of the heart chambers by echocardiography.

Results: Patients in both groups did not differ by age, blood pressure, percent of CAD and impaired glucose tolerance. IGF-1 levels were not significantly different among the study groups (210.1 and 216.6 ng/ml, p>0.05). High circulating IGF-1 levels were frequently observed in Group 2 (in 50% and 25% patients, respectively; р=0.039). The concentric remodeling for patients with normal IGF-1 seen in 38% of patients compared to 52% in patients with high level of IGF-1. The eccentric hypertrophy for patients with normal IGF-1 was not observed compared to 16% in patients with high level of IGF-1. The concentric hypertrophy for patients with normal IGF-1 was 30.7% compared to 4% in patients with high level of IGF-1.

Conclusions: IGF-1 has a significant effect on cardiac remodeling in patients with coronary artery disease and obesity. IGF-1 may be an important marker of prognosis of chronic heart failure in patients with obesity and an indicator of hypertension and associated cardiac remodeling.

About the authors

Olga Shpagina

Endocrinology Research Centre

Author for correspondence.
SPIN-code: 3114-2272

Russian Federation postgraduate student

Irina Bondarenko

Endocrinology Research Centre

SPIN-code: 4524-4803

Russian Federation MD, ScD

Maria Kuklina

Endocrinology Research Centre


Russian Federation PhD

Oksana Manchenko

Endocrinology Research Centre


Russian Federation PhD

Galina Kolesnikova

Endocrinology Research Centre

SPIN-code: 7716-9680

Russian Federation MD, ScD

Nikolai Goncharov

Endocrinology Research Centre


Russian Federation MD, ScD, prof


  1. Zheng W, McLerran DF, Rolland B, et al. Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians. N Engl J Med. 2011;364(8):719-729. doi: 10.1056/NEJMoa1010679.
  2. Sharma A, Vallakati A, Einstein AJ, et al. Relationship of Body Mass Index With Total Mortality, Cardiovascular Mortality, and Myocardial Infarction After Coronary Revascularization: Evidence From a Meta-analysis. Mayo Clin Proc. 2014;89(8):1080-1100. doi: 10.1016/j.mayocp.2014.04.020.
  3. Twickler MT, Cramer MJ, Koppeschaar HP. Unraveling Reaven’s syndrome X: serum insulin-like growth factor-I and cardiovascular disease. Circulation. 2003;107(20):e190–e192.
  4. Empen K, Lorbeer R, Volzke H, et al. Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania. Eur J Endocrinol. 2010;163(4):617-623. doi: 10.1530/eje-10-0563.
  5. Kinugawa S. Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes. Cardiovasc Res. 1999;43(1):157-164. doi: 10.1016/s0008-6363(99)00058-9.
  6. Sesti G, Sciacqua A, Scozzafava A, Vatrano M. Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients. J Hypertens. 2007;25(2):471-7.
  7. Rosén T, Wirén L, Wilhelmsen L, et al. Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf). 1994;40(1):111-116. doi: 10.1111/j.1365-2265.1994.tb02452.x.
  8. Cordido F, Garcia-Buela J, Sangiao-Alvarellos S, et al. The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors. Mediators Inflamm. 2010;2010:1-8. doi: 10.1155/2010/434562.
  9. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26- year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67(5):968-977. doi: 10.1161/01.cir.67.5.968.
  10. Kawachi S, Takeda N, Sasaki A, et al. Arterioscler Thromb Vasc Biol. Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2005;25:617-621 doi: 10.1161/01.ATV.0000154486.03017.35
  11. Chisalita SI, Dahlstrom U, Arnqvist HJ, Alehagen U. Increased IGF1 levels in relation to heart failure and cardiovascular mortality in an elderly population: impact of ACE inhibitors. Eur J Endocrinol. 2011;165(6):891-898. doi: 10.1530/eje-11-0584.
  12. Fischer F, Schulte H, Mohan S, et al. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Clin Endocrinol (Oxf). 2004;61(5):595-602. doi: 10.1111/j.1365-2265.2004.02136.x.
  13. Janssen JAMJL, Stolk RP, Pols HAP, et al. Serum Total IGF-I, Free IGF-I, and IGFBP-1 Levels in an Elderly Population : Relation to Cardiovascular Risk Factors and Disease. Arterioscler Thromb Vasc Biol. 1998;18(2):277-282. doi: 10.1161/01.atv.18.2.277.
  14. Juul A, Scheike T, Davidsen M, et al. Low Serum Insulin-Like Growth Factor I Is Associated With Increased Risk of Ischemic Heart Disease: A Population-Based Case-Control Study. Circulation. 2002;106(8):939-944. doi: 10.1161/
  15. Ganau A, Devereux RB, Roman MJ, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19(7):1550-1558. doi: 10.1016/0735-1097(92)90617-v.
  16. de Simone G, Palmieri V, Bella JN, et al. Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study. J Hypertens. 2002;20(2):323-331. doi: 10.1097/00004872-200202000-00024.
  17. Morgan HE, Baker KM. Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation. 1991;83(1):13-25. doi: 10.1161/01.cir.83.1.13.
  18. Duerr RL, Huang S, Miraliakbar HR, et al. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 1995;95(2):619-627. doi: 10.1172/jci117706.
  19. Welch S. Cardiac-Specific IGF-1 Expression Attenuates Dilated Cardiomyopathy in Tropomodulin-Overexpressing Transgenic Mice. Circ Res. 2002;90(6):641-648. doi: 10.1161/01.res.0000013780.77774.75.
  20. Osterziel KJ, Strohm O, Schuler J, et al. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. The Lancet. 1998;351(9111):1233-1237. doi: 10.1016/s0140-6736(97)11329-0.



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Copyright (c) 2016 Шпагина О.В., Бондаренко И.З., Куклина М.Д., Манченко О.В., Колесникова Г.С., Гончаров Н.П.

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