Relationship of IGF-1 and cardiac remodeling in overweight patients

Abstract


Objectives: To investigate the role of IGF-1 in the development of cardiac remodeling in patients with overweight and mild obesity.

Materials and Methods: The study included 75 men (mean age 55.3 ± 6.3 years), which are overweight or have mild obesity (body mass index (BMI) 28.6 ± 3.6) without diabetes. Group 1 included 46 patients with normal weight and overweight (BMI 26.5 ± 3.6). Group 2 included 27 patients with obesity (mean BMI 32.4 ± 3.5). Coronary artery disease was confirmed by treadmill test and coronarography. All participants were evaluated by impaired glucose tolerance test (IGT), cholesterol, triglycerides (TG), IGF-1 and LPHD, and LPLD levels, geometry of the heart chambers by echocardiography.

Results: Patients in both groups did not differ by age, blood pressure, percent of CAD and impaired glucose tolerance. IGF-1 levels were not significantly different among the study groups (210.1 and 216.6 ng/ml, p>0.05). High circulating IGF-1 levels were frequently observed in Group 2 (in 50% and 25% patients, respectively; р=0.039). The concentric remodeling for patients with normal IGF-1 seen in 38% of patients compared to 52% in patients with high level of IGF-1. The eccentric hypertrophy for patients with normal IGF-1 was not observed compared to 16% in patients with high level of IGF-1. The concentric hypertrophy for patients with normal IGF-1 was 30.7% compared to 4% in patients with high level of IGF-1.

Conclusions: IGF-1 has a significant effect on cardiac remodeling in patients with coronary artery disease and obesity. IGF-1 may be an important marker of prognosis of chronic heart failure in patients with obesity and an indicator of hypertension and associated cardiac remodeling.


About the authors

Olga Shpagina

Endocrinology Research Centre

Author for correspondence.
Email: shpagina_olga@mail.ru
SPIN-code: 3114-2272

Russian Federation postgraduate student

Irina Bondarenko

Endocrinology Research Centre

Email: iz_bondarenko@mail.ru
SPIN-code: 4524-4803

Russian Federation MD, ScD

Maria Kuklina

Endocrinology Research Centre

Email: m_kuklina@mail.ru

Russian Federation PhD

Oksana Manchenko

Endocrinology Research Centre

Email: xana03@mail.ru

Russian Federation PhD

Galina Kolesnikova

Endocrinology Research Centre

Email: kkk@mail.ru
SPIN-code: 7716-9680

Russian Federation MD, ScD

Nikolai Goncharov

Endocrinology Research Centre

Email: ng@mail.ru

Russian Federation MD, ScD, prof

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Copyright (c) 2016 Шпагина О.В., Бондаренко И.З., Куклина М.Д., Манченко О.В., Колесникова Г.С., Гончаров Н.П.

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