Silent pituitary adenomas: review and clinical cases


Silent, or clinically nonfunctioning adenomas are morphologically heterogeneous group, characterized by positive immunoreactivity for one or more hormones classically secreted by normal pituitary cells but without clinical expression. Although in some occasions enhanced or changed secretory activity can develop over time. According to immunoreactivity they are divided into "silent" gonado-, cortico-, somato -, mammo – and thyrotropinomas, oncocytomas, «zero-cell» tumors. All types of "silent" adenomas have different biological activity, secretory capacity and outcomes in the postoperative period. This series of clinical cases shows more «aggressiveness», a higher risk of relapse for "silent" cortico- and somatotropinomas. Immunohistochemical analysis of residual tissue can be used to identify patients with high risk of recurrence, to develop optimal treatment and follow-up.

About the authors

Anna Konstantinovna Lipatenkova

Endocrinology Research Centre

Author for correspondence.

Russian Federation PhD student

Larisa Konstantinovna Dzeranova

Endocrinology Research Centre


Russian Federation MD, PhD, leading researcher at the Department of Neuroendocrinology and ostepaty

Ekaterina Aleksandrovna Pigarova

Endocrinology Research Centre


Russian Federation Ph.D., senior researcher at the Department of Neuroendocrinology and ostepaty

Ludmila Igorevna Astaf'eva

Burdenko Neurosurgery Institute


Russian Federation MD, PhD, a physicianat the 8th Neurosurgery department

Andrey Yur'evich Grigor'ev

Endocrinology Research Centre


Russian Federation MD, PhD, head of the Neurosurgery department

Ludmila Valentinovna Shishkina

Burdenko Neurosurgery Institute


Russian Federation PhD, Head of the  Neyropatomorfologii department

Vladislav Yur'evich Cherebilo

Almazov federal heart blood and endocrinology centre


Russian Federation neurosurgeon at the Department of Neurosurgery

Anastasiya Pavlovna Ektova

Russian Pediatric Clinical Hospital


Russian Federation physicianat the Pathomorphology department


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Abstract - 1982

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Copyright (c) 2015 Липатенкова А.К., Дзеранова Л.К., Пигарова Е.А., Астафьева Л.И., Григорьев А.Ю., Шишкина Л.В., Черебило В.Ю., Эктова А.П.

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