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Ожирение и метаболизм

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Роль гормонов жировой ткани в развитии осложнений беременности у женщин с ожирением

Аннотация

Ожирение во время беременности – фактор риска развития осложнений как со стороны матери, так и со стороны плода. Гормоны жировой ткани (лептин, адипонектин, резистин) секретируются плацентой человека и регулируют функцию трофобласта. В обзоре представлены данные литературы о роли адипоцитокинов в развитии гестационного сахарного диабета и преэклампсии у женщин с ожирением. Рассмотрены критерии и алгоритмы диагностики гестационного сахарного диабета, рекомендованные Всемирной организацией здравоохранения и Международной ассоциацией исследовательских групп по диабету и беременности.

Об авторах

N A Petunina

д.м.н., проф., зав. кафедрой эндокринологии


I A Kuzina

старший лаборант кафедры эндокринологии


Список литературы

1. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Под редакцией акад. РАН и РАМН И.И. Дедова, М.В. Шестаковой. 5-й выпуск. М., 2011.

2. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15: 539–553.

3. Amaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br. J. Pharmacol. 2012;165 (3):622—632.

4. Barbour LA, McCurdy CE, Hernandez TL et al. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30 (Suppl. 2):S112–S119.

5. Bodnar LM et al. The risk of preeclampsia rises with increasing prepregnancy body mass index. Annals of Epidemiology. 2005;15(7):475–482.

6. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115:e290–e296.

7. Catalano PM, Hoegh M, Minium J et al. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia. 2006;49:1677–1685.

8. Challier J, Galtier M, Bintein T, Cortez A, Lepercq J, Hauguel-de Mouzon S. Placental leptin receptor isoforms in normal and pathological pregnancies. Placenta. 2003;24:92–99.

9. Сhen J, Tan B, Karteris E, et al. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia. 2006;49:1292–1302.

10. Cortelazzi D, Corbetta S, Ronzoni S et al. Maternal and foetal resistin and adiponectin concentrations in normal and complicated pregnancies. Clinical Endocrinology. 2007;66:447–453.

11. D'Anna R, Baviera G, Cannata ML et al. Midtrimester amniotic fluid leptin and insulin levels and subsequent gestational diabetes. Gynecologic and Obstetric Investigation. 2007;64:65–68.

12. D'Anna R, Baviera G, Corrado F, et al. Plasma adiponectin concentration in early pregnancy and subsequent risk of hypertensive disorders. Obstetrics and Gynecology. 2005;106:340–344.

13. Esakoff TF, Cheng YW, Sparks TN, Caughey AB. The association between birthweight 4000 gm or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am. J. Obstet. Gynecol. 2009;672:E1–E4.

14. Guelinckx I. еt al. Maternal obesity: pregnancy complications, gestational weight gain and nutrition. Obesity Reviews. 2008;9:140-150.

15. Haugen F, Ranheim T, Harsem NK et al. Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. American Journal of Physiology, Endocrinology and Metabolism. 2006;290:E326–E333.

16. Hauguel-De Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. American Journal of Obstetrics and Gynecology. 2006;194:1537–1545.

17. Inoue S, Takamoto N, Akahori Y et al. Elevated level of serum retinol-binding protein 4 in pregnancy-induced hypertension. The Journal of Obstetrics and Gynaecology Research. 2009;35:293–300.

18. International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care. 2010;33(3):676–682.

19. Jarvenpaa J, Vuoristo JT, Santaniemi M, Ukkola O, Savolainen ER, Jääskeläinen M, Tapanainen JS, Kesäniemi A, Ryynanen M. Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR. J. Perinat. Med. 2009;37:257–262.

20. Kajantie E, Hytinantti T, Hovi P et al. Cord plasma adiponectin: a 20-fold rise between 24 weeks gestation and term. Journal of Clinical Endocrinology and Metabolism. 2004;89:4031–4036.

21. Kajantie E, Kaaja R, Ylikorkala O et al. Adiponectin concentrations in maternal serum: elevated in preeclampsia but unrelated to insulin sensitivity. Journal of the Society for Gynecologic Investigation. 2005;12:433–439.

22. Kristensen J et al. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG:An International Journal of Obstetrics and Gynaecology. 2005;112(4):403–408.

23. Mazaki-Tovi S, Romero R, Kusanovic JP, et al. Maternal visfatin concentration in normal pregnancy. Journal of Perinatal Medicine. 2009;37:206–217.

24. McCance DR, Maresh M, Sacks DA. A Practicial manual of Diabetes in Pregnancy. Wiley BlackWell. 2010.

25. McDonald EA, Wolfe MW. The pro-inflammatory role of adiponectin at the maternal–fetal interface. Am. J. Reprod. Immunol. 2011;66:128–136.

26. McLachlan KA, O'Neal D, Jenkins A, et al. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes/Metabolism Research and Reviews. 2006;22:131–138.

27. Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, Dyer AR, Leiva A, Hod M, Kitzmiler JL, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33:676–682.

28. Miehle K, Holger S, Fasshauer M. Leptin, Adiponectin and other Adipokines in Gestational Diabetes Mellitus and Pre-eclampsia. Clin Endocrinol. 2012;76(1):2–11.

29. Misra VK, Trudeau S. The Influence of Overweight and Obesity on Longitudinal Trends in Maternal Serum Leptin Levels During Pregnancy. Obesity. 2011;192:416–421.

30. Moore LE, Wallace KL, Alexander BT, et al. Reduced placental perfusion causes an increase in maternal serum leptin. Placenta. 2003;24:877–881.

31. Nanda S, Yu CK, Giurcaneanu L, et al. Maternal serum adiponectin at 11–13 weeks of gestation in preeclampsia. Fetal Diagnosis and Therapy. 2011;29:208–215.

32. Nien JK, Mazaki-Tovi S, Romero R, et al. Resistin: a hormone which induces insulin resistance is increased in normal pregnancy. Journal of Perinatal Medicine. 2007;35:513–521.

33. Ning Y, Williams MA, Muy-Rivera M, et al. Relationship of maternal plasma leptin and risk of pre-eclampsia: a prospective study. The Journal of Maternal-Fetal & Neonatal Medicine. 2004;15:186–192.

34. Odden N, Morkrid L. High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. Clinical Endocrinology. 2007;67:891–896.

35. Ognjanovic S, Tashima LS, Bryant-Greenwood GD. The effects of pre-B-cell colony-enhancing factor on the human fetal membranes by microarray analysis.American Journal of Obstetrics and Gynecology. 2003;189:1187–1195.

36. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated proteinkinase and Akt signaling in endothelial cells. J.Biol.Biol.Chem. 2004;279:1304–1309.

37. Ouchi N, Parker JL, Lugus JJ, et al. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011;11:85–97.

38. Qiu C, Williams MA, Vadachkoria S, et al. Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus. Obstetrics and Gynecology. 2004;103:519–525.

39. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. Journal of Clinical Endocrinology and Metabolism. 2008;93:S64–S73.

40. Robinson HE, et al. Maternal outcomes in pregnancies complicated by obesity. Obstetrics and Gynecology. 2005;106(6):1357–1364.

41. Samolis S, Papastefanou I, Panagopoulos P, et al. Relation between first trimester maternal serum leptin levels and body mass index in normotensive and pre-eclamptic pregnancies – role of leptin as a marker of pre-eclampsia: a prospective case-control study. Gynecological Endocrinology. 2010;26:338–343.

42. Sirimi N, Goulis DG. Obesity in pregnancy. Hormones. 2010; 9(4):299-306

43. Steegers EA, von Dadelszen P, Duvekot JJ, et al. Pre-eclampsia. Lancet. 2010;376:631–644.

44. Ueland T, Dalsoren T, Voldner N, et al. Retinol-binding protein-4 is not strongly associated with insulin sensitivity in normal pregnancies. European Journal of Endocrinology. 2008;159:49–54.

45. Vahratian A, et al. Maternal pre-pregnancy overweight and obesity and the risk of cesarean delivery in nulliparous women. Annals of Epidemiology. 2005;15(7):467–474.

46. Vaisbuch E, Mazaki-Tovi S, Kusanovic J.P, et al. Retinol binding protein 4: an adipokine associated with intra-amniotic infection/inflammation. The Journal of Maternal-Fetal & Neonatal Medicine. 2010;23:111–119.

47. Weiwei T, Haiyan T, Juan C, Xiaodong W., Weibo C, Rong Z. Expressions of adiponectin receptors in placenta and their correlation with preeclampsia. Reprod. Sci. 2009;16:676–684.

48. Wendland EM, Torloni MR, Falavigna M, Trujillo J, Dode MA, Campos MA, Duncan BB, Schmidt MI. Gestational Diabetes and Pregnancy Outcomes. A Systematic Review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) Diagnostic Criteria. BMC Pregnancy Childbirth. 2012;12(23).

49. Yogev Y, Catalano PM. Pregnancy and Obesity. Obstet. Gynecol. Clin.N.Am. 2009;36:285–300.


Рецензия

Для цитирования:


Petunina N.A., Kuzina I.A. Роль гормонов жировой ткани в развитии осложнений беременности у женщин с ожирением. Ожирение и метаболизм. 2013;10(1):3-8.

For citation:


, The role of hormones of adipose tissue in the development pregnancy complications in obese women. Obesity and metabolism. 2013;10(1):3-8. (In Russ.)

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