Antidiabeticheskiy biguanid metforminkak geroprotektor i antikantserogen

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Abstract


Growth hormone (GH)/insulin-like growth factor 1 (IGF-1)/insulin, DAF-2 and insulin-receptor control life span in various species
including human. It is possible that the life-prolonging effect of calorie restriction is due to a decrease in IGF-1 levels. A search for pharmacological
modulators of life-span-extending mutations in the GH/IGF-1/insulin signaling pathway and mimetics of caloric restriction is a priority
direction in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates
for both life span extension and prevention of cancer

Email: aging@mail.ru

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